The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1.
Hepatitis B virus infection (HBV) is a major risk red pygmy dogwood factor for the development of hepatocellular carcinoma.HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs.The regulatory protein HBx has been shown